合成药化实验

合成药物化学实验 Experimental Synthetic Medicinal Chemistry

继实验药物化学课程之后，本课程通过更多的实验训练，使学生进一步熟练掌握有机合成和药物合成的操作和技巧，旨在认识药物合成路线和提取方法，培养、提高学生的动手能力，巩固基础理论知识，为今后的药物化学研究工作奠定扎实的基础。

Following Experimental Medicinal Chemistry, this course gives students advanced training of practical skills and operations in organic synthesis. It aims for the improvement on the hands-on ability of students and the consolidation of their basic theory of knowledge, which should provide solid foundation for future research work on medicinal chemistry.

主讲教师：李炜、王洁、肖莉纳

教学进度安排：
              内  容                                                                                                  学时
实验1  实验须知/发仪器/检查、调试仪器设备及其清洗、整理                   6
实验2  氯霉素的合成：1）对硝基-α-溴代苯乙酮的制备                              6
                     2）对硝基-α-氨基苯乙酮盐酸盐的制备I                                    6
                     3）对硝基-α-氨基苯乙酮盐酸盐的制备II                                   6
                     4）对硝基-α-乙酰氨基苯乙酮的制备                                         6
                     5）对硝基-α-乙酰氨基-β羟基苯丙酮的制备                              6
                     6）DL-苏-1-对硝基苯基-2-氨基-1,3-丙二醇的制备I                 6
                     7）DL-苏-1-对硝基苯基-2-氨基-1,3-丙二醇的制备II                6
                     8）消旋氯霉素的制备                                                                   6
                     9）消旋氯霉素的精制                                                                   6
实验3  吲哚美辛的合成：1）对甲氧基苯肼磺酸钠的制备I                           6
                       2）对甲氧基苯肼磺酸钠的制备II                                               6
                       3）N1-对甲氧基苯基对氯苯甲酰肼的制备                               6
                       4）吲哚美辛粗品的制备                                                              6
                       5）吲哚美辛晶型的转换                                                              6